Using cutting edge, non-invasive, in vivo diffusion imaging techniques combined with HDFT analysis and visualization, our lab seeks to advance clinical research in the diagnosis and treatment of neurological pathology and trauma. We collaborate with the Neurological Surgery Department at UPMC to visualize fiber tracts within the brain in three dimensions in order to plan the most effective and least damaging pathways of tumor excision in patients suffering from various forms of brain cancer. Additionally, we are engaged in a DARPA funded HDFT project to localize the fiber breaks caused by traumatic brain injuries (TBI), which cannot be seen with the current standard computed axial tomography (CAT or CT) scans or magnetic resonance (MR) imaging, aiding the diagnosis and prognosis of patient brain trauma.